Inheritance — IGCSE Biology (0970) questions by topic

Genetics problems here trace a pedigree diagram to explain how albinism passes through a family, calculate the probability that a child of two heterozygous cystic fibrosis carriers is affected, state what genes actually code for, and work out a cross between red- and white-flowered pea plants across two generations.

Choose, state, explain, identify and calculate carry 1 to 14 marks across 39 real questions from 2023 to 2025 papers. Because a single wrong ratio or misread genotype throws off an entire cross calculation, submitting worked probability answers for instant marking catches that error at the exact step it occurred, rather than after the whole cross has been completed.

May–June 2025, Paper 11

Question 32 · 1 mark

What are alternative forms of genes called? A alleles B chromosomes C genotypes D phenotypes

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May–June 2025, Paper 12

Question 29 · 1 mark

What is an alternative form of a gene called? A allele B chromosome C genotype D protein

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Question 30 · 1 mark

Cystic fibrosis is an inherited condition that occurs when an individual is homozygous for the recessive allele. If both parents are heterozygous for this characteristic, what is…

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May–June 2025, Paper 21

Question 29 · 1 mark

The diagram shows the chromosomes in the nucleus of a cell that divides by mitosis. The parent nucleus contains a set of chromosomes. Which diagram shows the chromosomes in the…

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Question 30 · 1 mark

A farmer bred together male cattle with white hair and female cattle with red hair. All the offspring produced had roan hair (a mixture of red and white). He then repeatedly bred…

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May–June 2025, Paper 22

Question 2 · 1 mark

Part of the base sequence of DNA from four species was determined. species 1 T C A G G A T T species 2 T G A G C A A T species 3 T G A G C A A G species 4 T G A G G A T T Which…

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Question 31 · 1 mark

The diagram shows the inheritance of a genetic condition in one family. The pedigree chart uses a key: shaded circle = female with condition; unshaded circle = female without…

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May–June 2024, Paper 12

Question 33 · 1 mark

What describes an allele? A an alternative form of a chromosome made of DNA B an alternative form of a chromosome made of protein C an alternative form of a gene made of DNA D an…

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May–June 2024, Paper 21

Question 7 · 1 mark

The diagram shows the sticky end of the DNA of a plasmid that has been cut by a restriction enzyme. The unpaired bases are labelled C A G T G. What is the correct sequence of the…

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Question 34 · 1 mark

The pedigree diagrams show the pattern of inheritance of a genetic disorder in four families (A–D). This genetic disorder is not sex-linked. Which pedigree diagram proves that the…

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May–June 2024, Paper 22

Question 7 · 1 mark

The diagram shows the bases in a section of DNA from one strand only: A−C−T−T−C−A−G−T−C. What is the base sequence on the complementary DNA strand? A G−C−T−T−C−G−A−T−C B…

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Question 33 · 1 mark

In a family, the two parents have blood groups A and B and the three children have blood groups B, B and O. What are the genotypes of the parents? A IAIA and IBIB B IAIB and IAIo…

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May–June 2024, Paper 32

Question 5 · 11 marks

The melanin gene in humans codes for a pigment produced in the skin, hair and eyes. Describe what is meant by the term gene.

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October–November 2024, Paper 12

Question 36 · 1 mark

What do genes code for?

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Question 37 · 1 mark

When white-flowered pea plants are crossed with red-flowered pea plants, the offspring plants all have red flowers. If these offspring plants are crossed, the next generation of…

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October–November 2024, Paper 22

Question 8 · 1 mark

Which base in a DNA molecule always pairs with a G base?

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Question 31 · 1 mark

Why do different cells in a human body produce different proteins?

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Question 32 · 1 mark

Which graph shows the mean mass of DNA per cell before, during and after mitosis? Graph A: starts at ~7 units, rises sharply, stays high, then returns to ~7 Graph B: starts at ~4…

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Question 33 · 1 mark

Which statement about gene mutations is correct?

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October–November 2024, Paper 42

Question 5 · 11 marks

Fig. 5.1 is a pedigree diagram showing the inheritance of blood group in one family. Individual 1 (male, blood group B) and individual 2 (female, blood group A) are parents. Their…

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May–June 2023, Paper 11

Question 33 · 1 mark

What is defined as a length of DNA that codes for a protein? A amino acid B antibody C chromosome D gene

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Question 34 · 1 mark

A man has three sons. What is the chance of his next child being a daughter? A 0% B 25% C 50% D 100%

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May–June 2023, Paper 12

Question 31 · 1 mark

Which human characteristics are inherited? The table considers blood group, eye colour, language and sex for rows A–D (key: shaded = inherited, blank = not inherited). A B C D

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Question 33 · 1 mark

When breeding, which pair of parents will be pure-breeding for a particular characteristic? A a heterozygous and a homozygous individual B two heterozygous individuals C two…

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Question 34 · 1 mark

In a pea plant, the allele for round seeds, R, is dominant to the allele for wrinkled seeds, r. If plants with the genotype Rr are crossed, what are the likely proportions of…

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May–June 2023, Paper 21

Question 8 · 1 mark

The structure of DNA involves two strands coiled together to form a double helix. Which pairing of bases between the two strands is correct? A A and G B A and T C C and A D C and T

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Question 30 · 1 mark

The statements describe how a protein is made. 1 mRNA passes through a ribosome. 2 mRNA molecules carry a copy of the gene to the cytoplasm. 3 The gene coding for the protein is…

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Question 31 · 1 mark

Which parents could produce offspring with blood group O? A heterozygous father with blood group A and heterozygous mother with blood group B B heterozygous father with blood…

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Question 32 · 1 mark

The diagram shows the inheritance of albinism in one family (a pedigree). Albinism is an inherited condition caused by a recessive allele. Individuals 1 and 2 are parents; 3, 4,…

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May–June 2023, Paper 22

Question 8 · 1 mark

DNA contains pairs of bases. Which pair shows a correct combination of bases? A A and C B C and G C G and A D T and G

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Question 30 · 1 mark

The following are involved in protein synthesis. 1 amino acids assembled in order 2 mRNA moves to the cytoplasm 3 mRNA passing through a ribosome 4 DNA in the nucleus In which…

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Question 31 · 1 mark

A man of genotype IAIo and woman of genotype IBIo have a child. What is the chance that the child will have the same blood group as one of its parents? A zero B 1 in 4 C 1 in 2 D…

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Question 32 · 1 mark

A man who has red-green colour blindness has a child with a woman who does not have red-green colour blindness. The child has red-green colour blindness. The man and woman decide…

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May–June 2023, Paper 41

Question 5 · 14 marks

Fig. 5.1 shows the stages involved in protein synthesis, with parts labelled X, Y and Z, and DNA and amino acid indicated. State the names of the parts labelled X, Y and Z in Fig.…

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May–June 2023, Paper 42

Question 2 · 10 marks

Fig. 2.1 is a diagram of part of a DNA molecule. Draw a circle on Fig. 2.1 to identify one pair of bases.

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October–November 2023, Paper 12

Question 33 · 1 mark

Two parents have the genotypes Bb and bb for a particular feature. What is the probability of these parents having offspring that are homozygous recessive for this feature? A 100%…

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Question 34 · 1 mark

A genetic cross between two organisms may be shown as Tt × Tt. What does T represent? A a dominant allele B a dominant chromosome C a recessive allele D a recessive chromosome

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October–November 2023, Paper 22

Question 32 · 1 mark

Why are cells in the pancreas the only body cells that produce insulin? A All of the genes in the nucleus of a cell in the pancreas are expressed. B Other body cells do not have…

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Question 38 · 1 mark

Red-green colour blindness is a sex-linked characteristic caused by a recessive allele. Which prediction can be made about the children of a woman who is colour-blind and a man…

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