Inheritance — IGCSE Biology (0610) questions by topic

Inheritance questions state which sex chromosome combination males and females carry, trace an albinism pedigree across several generations, name what different versions of a gene are called, and calculate the probability that two heterozygous cystic fibrosis carriers have an affected child.

Identify, state, explain, describe and complete carry 1 to 20 marks, the widest range for this topic, across 74 real questions from 2023 to 2025 papers. Because probability questions compound any earlier misidentified genotype, submitting each worked cross for instant marking flags a wrong allele combination at the exact step it appears, rather than after the full calculation.

May–June 2025, Paper 11

Question 32 · 1 mark

What are alternative forms of genes called? A alleles B chromosomes C genotypes D phenotypes

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May–June 2025, Paper 12

Question 29 · 1 mark

What is an alternative form of a gene called? A allele B chromosome C genotype D protein

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Question 30 · 1 mark

Cystic fibrosis is an inherited condition that occurs when an individual is homozygous for the recessive allele. If both parents are heterozygous for this characteristic, what is…

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May–June 2025, Paper 13

Question 28 · 1 mark

An individual has the genotype Bb. What is the correct description of this genotype? A heterozygous, with two different alleles of the same gene B heterozygous, with two different…

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Question 29 · 1 mark

Which statement describes inheritance? A organisms which are not pure-breeding B the difference between homozygous and heterozygous genotypes C the genetic information in dominant…

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May–June 2025, Paper 21

Question 5 · 1 mark

A DNA molecule contains pairs of bases. What is a correct combination of a pair of bases? A A and G B C and A C G and T D T and A

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Question 29 · 1 mark

The diagram shows the chromosomes in the nucleus of a cell that divides by mitosis. The parent cell nucleus contains six chromosomes (three pairs of differing shapes/lengths).…

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Question 30 · 1 mark

A farmer bred together male cattle with white hair and female cattle with red hair. All the offspring produced had roan hair (a mixture of red and white). He then repeatedly bred…

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Question 31 · 1 mark

Phagocytes and neurones are two types of specialised cell. Which statements are correct? 1 Phagocytes and neurones express the same genes. 2 Both types of cell have the same…

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May–June 2025, Paper 22

Question 31 · 1 mark

The diagram shows the inheritance of a genetic condition in one family across three generations. In the pedigree, affected individuals (both male and female) appear in each…

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May–June 2025, Paper 23

Question 4 · 1 mark

In a DNA molecule, bonds between pairs of bases hold two strands together. High temperatures can break these bonds to form two single strands of DNA. The base pair C and G is held…

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Question 30 · 1 mark

Which name is given to different versions of a gene? A allele B chromosome C length of DNA D protein

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Question 31 · 1 mark

The diagram shows the cells of a mammalian embryo shortly after fertilisation. [Diagram: a cluster of several similar cells (a ball of cells), each containing a nucleus, showing…

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Question 32 · 1 mark

The diagram shows the inheritance, in one family, of a sex-linked recessive disease. [Pedigree diagram with key: circle = female, square = male; shaded = affected, unshaded =…

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May–June 2024, Paper 32

Question 5 · 11 marks

The melanin gene in humans codes for a pigment produced in the skin, hair and eyes. Describe what is meant by the term gene.

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May–June 2024, Paper 33

Question 3 · 12 marks

Fig. 3.1 is a pedigree diagram for a plant that can have either blue flowers or purple flowers. Blue flower colour is dominant to purple flower colour. The allele for blue flowers…

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May–June 2024, Paper 42

Question 3 · 11 marks

Meiosis and mitosis are important processes in the life cycles of organisms. Fig. 3.1 shows the life cycles of two different organisms. Organism 1 has a simple life cycle (adult…

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May–June 2024, Paper 43

Question 3 · 10 marks

Proteins are biological molecules. Explain how proteins are made.

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October–November 2024, Paper 11

Question 35 · 1 mark

Which sex chromosomes need to be present in a sperm cell to produce a male offspring? A X only B Y only C XX D XY

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October–November 2024, Paper 12

Question 36 · 1 mark

What do genes code for? A fats B proteins C starch D sugars

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Question 37 · 1 mark

When white-flowered pea plants are crossed with red-flowered pea plants, the offspring plants all have red flowers. If these offspring plants are crossed, the next generation of…

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October–November 2024, Paper 13

Question 31 · 1 mark

Which sex chromosomes are present in a human sperm cell? A both X and Y chromosomes B either X or Y chromosomes C only X chromosomes D only Y chromosomes

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Question 32 · 1 mark

What are alleles made of? A amino acids B DNA C genes D protein

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October–November 2024, Paper 21

Question 30 · 1 mark

Where are amino acids assembled into protein molecules? A the DNA B the genes C the nucleus D the ribosomes

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Question 31 · 1 mark

The diagram shows the changes in the mass of DNA in one cell before, during and after mitosis, with point X marked where the mean mass of DNA per cell doubles. What is happening…

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Question 32 · 1 mark

A woman who has blood group AB has a child with a man who has blood group B and is heterozygous. What is the chance of the child having blood group B? A 0% B 25% C 50% D 100%

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October–November 2024, Paper 22

Question 8 · 1 mark

Which base in a DNA molecule always pairs with a G base? A A B G C C D T

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Question 31 · 1 mark

Why do different cells in a human body produce different proteins? A Alleles can be dominant or recessive. B Only particular genes are expressed. C Cells have different genes. D…

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Question 32 · 1 mark

Which graph shows the mean mass of DNA per cell before, during and after mitosis? (mean mass of DNA per cell / arbitrary units against time, options A-D) A graph A B graph B C…

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October–November 2024, Paper 23

Question 29 · 1 mark

Which description of a human gamete is correct? A a diploid cell with 23 chromosomes B a diploid cell with 46 chromosomes C a haploid cell with 23 chromosomes D a haploid cell…

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Question 30 · 1 mark

Which statements about meiosis are correct? (columns: produces genetically identical cells; involved in the production of gametes) A yes; no B yes; yes C no; yes D no; no

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Question 31 · 1 mark

A female parent who is heterozygous for red-green colour blindness has a female child with a red-green colour-blind male parent. What is the chance of the female child being…

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Question 32 · 1 mark

A pure-breeding plant with smooth stems was crossed with a heterozygous plant with hairy stems. What will be the ratio of hairy to smooth stems in the resulting plants? A 1 hairy…

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October–November 2024, Paper 41

Question 5 · 7 marks

The gene for red-green colour vision is on the X chromosome. There are two alleles for this gene: the allele for normal colour vision is represented by the letter B; the allele…

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October–November 2024, Paper 42

Question 5 · 11 marks

Fig. 5.1 is a pedigree diagram showing the inheritance of blood group in one family. State the number of people in Fig. 5.1 with: XY chromosomes; only one IA allele.

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October–November 2024, Paper 43

Question 6 · 20 marks

Some blood-clotting disorders can be inherited. Describe what is meant by the term inheritance.

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May–June 2023, Paper 11

Question 33 · 1 mark

What is defined as a length of DNA that codes for a protein? A amino acid B antibody C chromosome D gene

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Question 34 · 1 mark

A man has three sons. What is the chance of his next child being a daughter? A 0% B 25% C 50% D 100%

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May–June 2023, Paper 12

Question 31 · 1 mark

Which human characteristics are inherited? Columns: blood group; eye colour; language; sex (key: ✓ = inherited, blank = not inherited). Which row A–D is correct? A B C D

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Question 33 · 1 mark

When breeding, which pair of parents will be pure-breeding for a particular characteristic? A a heterozygous and a homozygous individual B two heterozygous individuals C two…

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Question 34 · 1 mark

In a pea plant, the allele for round seeds, R, is dominant to the allele for wrinkled seeds, r. If plants with the genotype Rr are crossed, what are the likely proportions of…

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May–June 2023, Paper 13

Question 33 · 1 mark

Which statement is correct? A Chromosomes are made of DNA. B Chromosomes make up a gene. C Each chromosome is a length of DNA that codes for a protein. D Different forms of…

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Question 34 · 1 mark

In a species of mammal, black fur colour is dominant and brown fur colour is recessive. Two parents with black fur produce offspring which all have black fur. Later that year, the…

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May–June 2023, Paper 21

Question 8 · 1 mark

The structure of DNA involves two strands coiled together to form a double helix. Which pairing of bases between the two strands is correct? A A and G B A and T C C and A D C and T

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Question 28 · 1 mark

Potatoes are stem tubers. A tuber can be placed in the ground to grow into another plant, which can grow many more tubers (asexual reproduction shown over 4 months). The diploid…

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Question 30 · 1 mark

The statements describe how a protein is made. 1 mRNA passes through a ribosome. 2 mRNA molecules carry a copy of the gene to the cytoplasm. 3 The gene coding for the protein is…

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Question 31 · 1 mark

Which parents could produce offspring with blood group O? A heterozygous father with blood group A and heterozygous mother with blood group B B heterozygous father with blood…

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Question 32 · 1 mark

The diagram shows the inheritance of albinism in one family. Albinism is an inherited condition caused by a recessive allele. The pedigree shows generations with unaffected…

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May–June 2023, Paper 22

Question 8 · 1 mark

DNA contains pairs of bases. Which pair shows a correct combination of bases? A A and C B C and G C G and A D T and G

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Question 30 · 1 mark

The following are involved in protein synthesis. 1 amino acids assembled in order 2 mRNA moves to the cytoplasm 3 mRNA passing through a ribosome 4 DNA in the nucleus In which…

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Question 31 · 1 mark

A man of genotype IᴬIᵒ and woman of genotype IᴮIᵒ have a child. What is the chance that the child will have the same blood group as one of its parents? A zero B 1 in 4 C 1 in 2 D…

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Question 32 · 1 mark

A man who has red-green colour blindness has a child with a woman who does not have red-green colour blindness. The child has red-green colour blindness. The man and woman decide…

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May–June 2023, Paper 23

Question 8 · 1 mark

What describes the structure of DNA? A Each strand contains chemicals called fatty acids. B Each strand contains a sequence of amino acids. C Each strand contains mRNA. D Two…

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Question 30 · 1 mark

Which substance is coded for by a length of DNA? A base B glucose C glycerol D lipase

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Question 31 · 1 mark

The diagram shows the sex chromosomes of a woman (genotype XᴬXᵃ) and of a man (genotype XᵃY) for a recessive sex-linked condition (key: A is dominant, a is recessive). What are…

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Question 32 · 1 mark

Which Punnett square shows a test cross that identifies a heterozygous parent? Each option A–D is a 2×2 Punnett square crossing a parent with gametes T/t or T/T against a…

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May–June 2023, Paper 41

Question 5 · 14 marks

Fig. 5.1 shows the stages involved in protein synthesis, with parts labelled X, Y and Z and amino acids being assembled. State the names of the parts labelled X, Y and Z in Fig.…

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May–June 2023, Paper 42

Question 2 · 10 marks

Fig. 2.1 is a diagram of part of a DNA molecule (a double helix with paired bases). Draw a circle on Fig. 2.1 to identify one pair of bases.

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October–November 2023, Paper 11

Question 33 · 1 mark

Which statement about the human sex chromosomes is correct? A Females have an X chromosome and a Y chromosome. B Females have two Y chromosomes. C Males and females have at least…

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Question 34 · 1 mark

The inheritance of seed colour in pea plants is controlled by a single gene. The allele for yellow seed colour, Y, is dominant. The allele for green seed colour, y, is recessive.…

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October–November 2023, Paper 12

Question 33 · 1 mark

Two parents have the genotypes Bb and bb for a particular feature. What is the probability of these parents having offspring that are homozygous recessive for this feature? A 100%…

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Question 34 · 1 mark

A genetic cross between two organisms may be shown as Tt × Tt. What does T represent? A a dominant allele B a dominant chromosome C a recessive allele D a recessive chromosome

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October–November 2023, Paper 13

Question 30 · 1 mark

A pea plant with the genotype YY is crossed with a pea plant with the genotype yy. What are the possible genotypes of the offspring? A YY and yy B all Yy C Yy and yy D all YY

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Question 34 · 1 mark

The diagram shows part of a genetic diagram for the inheritance of sex in humans. The parents are father and mother; the father's gametes are X and gamete 1, and the mother's…

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October–November 2023, Paper 21

Question 31 · 1 mark

Which row shows correct information about mitosis? Columns: cells produced by mitosis (compared genetically with parent); number of chromosomes in the daughter cells compared to…

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Question 32 · 1 mark

Polydactyly is a condition that can occur in cats, resulting in affected individuals having extra toes. The diagram shows the inheritance of the condition in a family of cats…

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Question 36 · 1 mark

In guinea pigs, the allele for black fur is dominant and the allele for white fur is recessive. A test cross can be used to determine the genotype of a guinea pig with black fur.…

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October–November 2023, Paper 22

Question 32 · 1 mark

Why are cells in the pancreas the only body cells that produce insulin? A All of the genes in the nucleus of a cell in the pancreas are expressed. B Other body cells do not have…

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Question 33 · 1 mark

Which statement is correct? A Mitosis always produces offspring that are homozygous. B Mitosis produces cells that are genetically identical. C Mitosis produces gametes in…

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Question 38 · 1 mark

Red-green colour blindness is a sex-linked characteristic caused by a recessive allele. Which prediction can be made about the children of a woman who is colour-blind and a man…

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October–November 2023, Paper 23

Question 33 · 1 mark

Pea plants produce either yellow or green seeds. Yellow (Y) is dominant to green (y). What are the most likely phenotypes of the offspring of a cross between YY and Yy plants? A…

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Question 34 · 1 mark

The diagram shows the chromosomes of a cell after they have replicated and just before the cell divides by mitosis. Which pair of cells will be produced at the end of mitosis?…

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Question 40 · 1 mark

Which statements are correct descriptions of parts of the process of protein synthesis? 1 Amino acids are made by the ribosomes. 2 mRNA is copied. 3 The gene coding for the…

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October–November 2023, Paper 41

Question 4 · 10 marks

Mitosis and meiosis are both important processes for life. Complete the sentences about mitosis and meiosis. Mitosis is a type of nuclear division which produces genetically…

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